failure of holism
Despite its philosophical appeal, holism has produced little or nothing of practical value. It has resulted in the development of some conceptually interesting mathematical frameworks (e.g. Chaos Theory), and some deep metaphysical principles (e.g. those of Buddhism). On the other hand, it has also laid the foundations of the Post-Modernist movement (e.g. the belief that truth is context dependent etc), and in some circles even led to the rise of an anti-scientist sentiment.